Nanofibers can be fabricated by using various techniques including electrospinning, drawing, self-assembly, template synthesis, and thermal-induced phase separation. Electrospinning is a versatile tool since it can form fibers ranging between 50-500 nm which is suitable for cell adhesion and migration. Electrospinning has been widely used for the fabrication of extracellular matrix (ECM)-mimicking fibrous scaffolds and drug delivery systems in last few decades. Electrospun natural and synthetic polymers and their blends are commonly being investigated for biomedical applications. The structural and chemical properties of the membranes strongly affect their field of use. In this study, (PVA)-gelatin (GE) nanocomposite fibers were produced by using electrospinning technique, and morphologic and chemical properties were investigated. The process parameters including the applied voltage, distance from collector and concentration were investigated. Electrospinning process were conducted at four different GE concentrations (PVA/GE= 10/0, 8/2, 6/4 and 0/10 wt%). Scanning electron microscopy (SEM) were used to determine the morphology and fiber diameters, and Fourier transform infrared spectroscopy (FTIR) was used to characterize chemical groups in nanofibers. Material properties of electrospun PVA/GE nanocomposite fibers were evaluated in comparison to fibers composed of solely PVA or GE. These studies demonstrated that the nanofibers obtained from this study are good candidates for tissue engineering and dental applications.
Anahtar Kelimeler: Electrospinning, Gelatin, Polyvinyl Alcohol, PVA/GE, Tissue Engineering