The drug delivery system is a general term that can control the release and delivery of drugs to the site of interest, allowing active pharmaceutical ingredients to maximize therapeutic efficacy. Hydrogels are hydrophilic polymer networks that can absorb large amounts of water, increase their volume, and exhibit different behaviors. The photopolymerization method, which provides the occurrence of solid polymer networks starting from monomers, has an interest in a wide variety fields of science. Diabetes is the top ten cause of death worldwide. Also, diabetes is a chronic disease in which the body's ability to regulate excess blood glucose levels is impaired. Metformin HCl, which is proposed as first-line therapy for diabetes, has been reported to be effective and safe.
This study aims to prepare and evaluate a photopolymerizable drug delivery system. The prepared hydrogels by UV photopolymerization have been characterized using FT-IR, SEM, and a digital microscope. Swelling studies were studied in deionized water, pH 1.2, 6.8, and 7.4. In-vitro drug release studies have been performed for hydrogels at pH 1.2, 6.8, and 7.4. Zero-order, First-order, Hixson-Crowell, and Korsmeyer-Peppas models were evaluated for drug release kinetic. The results showed that produced hydrogels are efficient for active pharmaceutical ingredient delivery. (ORCID NO: 0000-0002-6420-995X)
Anahtar Kelimeler: Photopolymerization, hydrogel, active pharmaceutical ingredient
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